Association of HIV Preexposure Prophylaxis With Incidence of Sexually Transmitted Infections Among Individuals at High Risk of HIV Infection
Michael W Traeger, Vincent J Cornelisse, Jason Asselin, Brian Price, Norman J Roth, Jeff Willcox, Ban Kiem Tee, Christopher K Fairley, Christina C Chang, Jude Armishaw, Olga Vujovic, Matthew Penn, Pauline Cundill, George Forgan-Smith, John Gall, Claire Pickett, Luxi Lal, Anne Mak, Tim D Spelman, Nguyen Long Show all
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | AMER MEDICAL ASSOC | Published : 2019
Importance: Emerging evidence suggests that risk of bacterial sexually transmitted infections (STIs) increases among gay and bisexual men following initiation of HIV preexposure prophylaxis (PrEP). Objective: To describe STI incidence and behavioral risk factors among a cohort of predominantly gay and bisexual men who use PrEP, and to explore changes in STI incidence following PrEP commencement. Design, Setting, and Participants: The Pre-exposure Prophylaxis Expanded (PrEPX) Study, a multisite, open-label intervention study, was nested within the Australian Collaboration for Coordinated Enhanced Sentinel Surveillance (ACCESS) clinic network. A total of 4275 participants were enrolled (July 2..View full abstract
Awarded by NHMRC
The Pre-exposure Prophylaxis Expanded (PrEPX) Study was supported by funding from the Victorian Department of Health and Human Services, Thorne Harbour Health, and Alfred Health. Dr Cornelisse receives a stipend from the research training program of the Australian government's Department of Education and Training. Dr Stoove is supported by a National Health and Medical Research Council (NHMRC) senior research fellowship. Dr Chang is supported by an NHMRC early career fellowship (APP1092160). The Burnet Institute gratefully acknowledges support received from the Victorian Operational Infrastructure Support Program. Gilead Sciences donated study drug to the VicPrEP study (precursor to this study).