Association of HIV Preexposure Prophylaxis With Incidence of Sexually Transmitted Infections Among Individuals at High Risk of HIV Infection

Michael W Traeger; Vincent J Cornelisse; Jason Asselin; Brian Price; Norman J Roth; Jeff Willcox; Ban Kiem Tee; Christopher K Fairley; Christina C Chang; Jude Armishaw; Olga Vujovic; Matthew Penn; Pauline Cundill; George Forgan-Smith; John Gall; Claire Pickett; Anne Mak; Tim D Spelman; Nguyen Long; Dean A Murphy; Kathleen E Ryan; Carol El-Hayek; Michael West; Simon Ruth; Colin Batrouney; John T Lockwood; Jennifer F Hoy; Margaret E Hellard; Mark A Stoove; Edwina J Wright; John de Wit; Luxi Lal; Jennifer Audsley; Alison Duncan; Joe Sasadeusz; Brent Allan; Michael Whelan; Daniel McPhail; David Wilson; Martin Holt; Chris Williams; Steve Wesselingh; James Ward; Danny Gallant; Alison Ward; Alistair Chong; Katharine McKinnon; Ivette Aguirre; Timothy Read; Richard Moore; Helan Lau; Danielle Collins; Sian Edwards; Susan Boyd; Emma Paige; Amanda Wade; Charlotte Bell; William Donohue; Samuel Elliot; Helen Calabretto; Louise Owen; Jenny Kelsall

Journal article

Association of HIV Preexposure Prophylaxis With Incidence of Sexually Transmitted Infections Among Individuals at High Risk of HIV Infection

Michael W Traeger, Vincent J Cornelisse, Jason Asselin, Brian Price, Norman J Roth, Jeff Willcox, Ban Kiem Tee, Christopher K Fairley, Christina C Chang, Jude Armishaw, Olga Vujovic, Matthew Penn, Pauline Cundill, George Forgan-Smith, John Gall, Claire Pickett, Anne Mak, Tim D Spelman, Nguyen Long, Dean A Murphy Show all

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | AMER MEDICAL ASSOC | Published : 2019

DOI: 10.1001/jama.2019.2947

Abstract

IMPORTANCE: Emerging evidence suggests that risk of bacterial sexually transmitted infections (STIs) increases among gay and bisexual men following initiation of HIV preexposure prophylaxis (PrEP). OBJECTIVE: To describe STI incidence and behavioral risk factors among a cohort of predominantly gay and bisexual men who use PrEP, and to explore changes in STI incidence following PrEP commencement. DESIGN, SETTING, AND PARTICIPANTS: The Pre-exposure Prophylaxis Expanded (PrEPX) Study, a multisite, open-label intervention study, was nested within the Australian Collaboration for Coordinated Enhanced Sentinel Surveillance (ACCESS) clinic network. A total of 4275 participants were enrolled (July 2..

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University of Melbourne Researchers

Margaret Hellard Author Infectious Diseases

Edwina Wright Author Infectious Diseases

Timothy Spelman Author Surgery - St Vincent's Hospital

Jennifer Audsley Author Infectious Diseases

Grants

Awarded by NHMRC

Funding Acknowledgements

The Pre-exposure Prophylaxis Expanded (PrEPX) Study was supported by funding from the Victorian Department of Health and Human Services, Thorne Harbour Health, and Alfred Health. Dr Cornelisse receives a stipend from the research training program of the Australian government's Department of Education and Training. Dr Stoove is supported by a National Health and Medical Research Council (NHMRC) senior research fellowship. Dr Chang is supported by an NHMRC early career fellowship (APP1092160). The Burnet Institute gratefully acknowledges support received from the Victorian Operational Infrastructure Support Program. Gilead Sciences donated study drug to the VicPrEP study (precursor to this study).