Journal article

Serum Calcification Propensity and Coronary Artery Calcification Among Patients with CKD: The CRIC (Chronic Renal Insufficiency Cohort) Study

Joshua D Bundy, Xuan Cai, Julia J Scialla, Mirela A Dobre, Jing Chen, Chi-yuan Hsu, Mary B Leonard, Alan S Go, Panduranga S Rao, James P Lash, Raymond R Townsend, Harold Feldman, Ian H de Boer, Geoffrey A Block, Myles Wolf, Edward R Smith, Andreas Pasch, Tamara Isakova, Lawrence J Appel, Jiang He Show all

AMERICAN JOURNAL OF KIDNEY DISEASES | W B SAUNDERS CO-ELSEVIER INC | Published : 2019

Abstract

RATIONALE & OBJECTIVE: Coronary artery calcification (CAC) is prevalent among patients with chronic kidney disease (CKD) and increases risks for cardiovascular disease events and mortality. We hypothesized that a novel serum measure of calcification propensity is associated with CAC among patients with CKD stages 2 to 4. STUDY DESIGN: Prospective cohort study. SETTING & PARTICIPANTS: Participants from the Chronic Renal Insufficiency Cohort (CRIC) Study with baseline (n=1,274) and follow-up (n=780) CAC measurements. PREDICTORS: Calcification propensity, quantified as transformation time (T50) from primary to secondary calciprotein particles, with lower T50 corresponding to higher calcificatio..

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Grants

Awarded by National Institutes of Health (NIH)


Awarded by National Institute of Diabetes and Digestive and Kidney Diseases


Awarded by Perelman School of Medicine at the University of Pennsylvania Clinical and Translational Science Award NIH/National Center for Advancing Translational Sciences


Awarded by Johns Hopkins Infstitute for Clinical and Translational Research


Awarded by University of Maryland General Clinical Research Center


Awarded by Clinical and Translational Science Collaborative of Cleveland


Awarded by Michigan Institute for Clinical and Health Research


Awarded by University of Illinois at Chicago Clinical and Translational Science Awards


Awarded by Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases


Awarded by Kaiser Permanente NIH/National Center for Research Resources UCSF-CTSI


Awarded by National Heart, Lung, and Blood Institute Cardiovascular Epidemiology training grant


Awarded by NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES


Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES


Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES


Funding Acknowledgements

This work was supported by grants P30DK114857, R01DK102438 (Dr Isakova), R01DK110087 (Dr Isakova), R01DK099199 (Dr de Boer), R01DK081374 (Dr Wolf), R01DK076116 (Dr Wolf), R01DK094796 (Dr Wolf), U01DK099930 (Drs Isakova and Wolf), R01DK111952 (Dr Scialla), and R01HL141846 (Dr Dobre) from the National Institutes of Health (NIH), and a Strategically Focused Research Network Center Grant on Health Disparities from the American Heart Association (Dr Wolf). Funding for the CRIC Study was obtained under a cooperative agreement from the National Institute of Diabetes and Digestive and Kidney Diseases (U01DK060990, U01DK060984, U01DK061022, U01DK061021, U01DK061028, U01DK060980, U01DK060963, and U01DK060902). In addition, this study was supported in part by the Perelman School of Medicine at the University of Pennsylvania Clinical and Translational Science Award NIH/National Center for Advancing Translational Sciences UL1TR000003, the Johns Hopkins Infstitute for Clinical and Translational Research UL1 TR-000424, University of Maryland General Clinical Research Center M01 RR-16500, Clinical and Translational Science Collaborative of Cleveland, UL1TR000439, Michigan Institute for Clinical and Health Research UL1TR000433, University of Illinois at Chicago Clinical and Translational Science Awards UL1RR029879, Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases P20 GM109036, and Kaiser Permanente NIH/National Center for Research Resources UCSF-CTSI UL1 RR-024131. Dr Bundy is supported by the National Heart, Lung, and Blood Institute Cardiovascular Epidemiology training grant T32HL069771. None of the funders of this study had any role in the current study design; collection, analysis, and interpretation of data; writing the report; or the decision to submit the report for publication.