Trophoblast function is altered by decidual factors in gestational-dependant manner
EM Menkhorst, M Van Sinderen, J Correia, E Dimitriadis
PLACENTA | W B SAUNDERS CO LTD | Published : 2019
Inadequate implantation and placentation is associated with miscarriage and placental insufficiency. The decidual environment is thought to regulate trophoblast invasion, however this is poorly defined in humans. We aimed to determine the effect of decidualization on trophoblast function. In vitro decidualized primary human endometrial stromal cells (HESC) significantly enhanced first-trimester extravillous trophoblast (EVT) (6-8-weeks gestation) adhesion, outgrowth/invasion. In EVTs from 10 to 12-weeks gestation this effect was absent (adhesion, invasion) or reversed (outgrowth). HESC conditioned media had no effect on trophoblast MMP9 production/activity. Decidualization regulated EVT func..View full abstract
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Awarded by NHMRC (Australia)
This work was supported by NHMRC (Australia) Project/Program Grant (GNT1027100) to ED and EM and by the Victorian Government's Operational Infrastructure Support Program. ED was supported by NHMRC (Australia) senior research fellowship (#550905). EM was supported by NHMRC (Australia) early career fellowship (#611827).