Journal article

Identifying optimal clinical scenarios for synchrotron microbeam radiation therapy: A treatment planning study

Lloyd ML Smyth, Liam R Day, Katrina Woodford, Peter AW Rogers, Jeffrey C Crosbie, Sashendra Senthi

PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS | ELSEVIER SCI LTD | Published : 2019

Abstract

PURPOSE: Synchrotron Microbeam Radiation Therapy (MRT) is a pre-clinical modality characterised by spatial dose fractionation on a microscopic scale. Treatment planning studies using clinical datasets have not yet been conducted. Our aim was to investigate MRT dose-distributions in scenarios refractory to conventional treatment and to identify optimal settings for a future Phase I trial. METHODS: MRT plans were generated for seven scenarios where re-irradiation was performed clinically. A hybrid algorithm, combining Monte Carlo and convolution-based methods, was used for dose-calculation. The valley dose to organs at risk had to respect the single fraction tolerance doses achieved in the cor..

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