Is strength training feasible for young people with Prader-Willi syndrome? A phase I randomised controlled trial

Abstract

OBJECTIVE: To investigate the feasibility of progressive resistance training for people with Prader-Willi syndrome (PWS), who have muscle weakness and very low muscle mass. DESIGN: Randomised controlled trial with concealed allocation, assessor blinding and intention-to-treat analysis. SETTING: Community gymnasium. PARTICIPANTS: Sixteen participants with PWS (eight female; mean age 25 years) were randomly assigned with 1:1 allocation to an experimental (n=8) or control group (n=8). INTERVENTION: Progressive resistance training was performed twice a week for 10 weeks. The training was supervised one-to-one by a physiotherapist and comprised seven exercises. The control group continued their u..