Journal article

Comparison of endothelial function and sympathetic nervous system activity along the glucose continuum in individuals with differing metabolic risk profiles and low dietary sodium intake

Sara Baqar, Nora E Straznicky, Gavin Lambert, Yee Wen Kong, John B Dixon, George Jerums, Elif Ilhan Ekinci, Elisabeth Lambert

BMJ OPEN DIABETES RESEARCH & CARE | BMJ PUBLISHING GROUP | Published : 2019

Abstract

OBJECTIVE: Low sodium intake may trigger sympathetic nervous system (SNS) activation and endothelial dysfunction. Studies have not explored these associations along the glucose continuum. Accordingly, we compared endothelial function and SNS activity in individuals with low sodium intake and differing categories of metabolic risk along the glucose continuum. We hypothesized that low sodium intake is associated with (1) impairment of endothelial function and (2) higher SNS activity in individuals with higher metabolic risk. RESEARCH DESIGN AND METHODS: In this prospective observational study, participants (n=54) with low sodium intake (single 24 hours urine sodium excretion <150 mmol/24 hours..

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