Eradication of carriage with methicillin-resistant Staphylococcus aureus: determinants of treatment failure.
Heidi SM Ammerlaan, Jan AJW Kluytmans, Hanneke Berkhout, Anton Buiting, Els IGB de Brauwer, Peterhans J van den Broek, Paula van Gelderen, Sander ACAP Leenders, Alewijn Ott, Clemens Richter, Lodewijk Spanjaard, Ingrid JB Spijkerman, Frank H van Tiel, G Paul Voorn, Mireille WH Wulf, Jan van Zeijl, Annet Troelstra, Marc JM Bonten, undefined MRSA Eradication Study Group
J Antimicrob Chemother | Published : 2011
BACKGROUND: Using data from an observational study in which the effectiveness of a guideline for eradication of methicillin-resistant Staphylococcus aureus (MRSA) carriage was evaluated, we identified variables that were associated with treatment failure. METHODS: A multivariate logistic regression model was performed with subgroup analyses for uncomplicated and complicated MRSA carriage (the latter including MRSA infection, skin lesions, foreign-body material, mupirocin resistance and/or exclusive extranasal carriage) and for those treated according to the guideline (i.e. mupirocin nasal ointment and chlorhexidine soap solution for uncomplicated carriage, in combination with two oral antibi..View full abstract