Journal article

Eradication of carriage with methicillin-resistant Staphylococcus aureus: determinants of treatment failure.

Heidi SM Ammerlaan, Jan AJW Kluytmans, Hanneke Berkhout, Anton Buiting, Els IGB de Brauwer, Peterhans J van den Broek, Paula van Gelderen, Sander ACAP Leenders, Alewijn Ott, Clemens Richter, Lodewijk Spanjaard, Ingrid JB Spijkerman, Frank H van Tiel, G Paul Voorn, Mireille WH Wulf, Jan van Zeijl, Annet Troelstra, Marc JM Bonten, undefined MRSA Eradication Study Group

J Antimicrob Chemother | Published : 2011

Abstract

BACKGROUND: Using data from an observational study in which the effectiveness of a guideline for eradication of methicillin-resistant Staphylococcus aureus (MRSA) carriage was evaluated, we identified variables that were associated with treatment failure. METHODS: A multivariate logistic regression model was performed with subgroup analyses for uncomplicated and complicated MRSA carriage (the latter including MRSA infection, skin lesions, foreign-body material, mupirocin resistance and/or exclusive extranasal carriage) and for those treated according to the guideline (i.e. mupirocin nasal ointment and chlorhexidine soap solution for uncomplicated carriage, in combination with two oral antibi..

View full abstract