Journal article

Eradication of carriage with methicillin-resistant Staphylococcus aureus: effectiveness of a national guideline.

Heidi SM Ammerlaan, Jan AJW Kluytmans, Hanneke Berkhout, Anton Buiting, Els IGB de Brauwer, Peterhans J van den Broek, Paula van Gelderen, Sander ACAP Leenders, Alewijn Ott, Clemens Richter, Lodewijk Spanjaard, Ingrid JB Spijkerman, Frank H van Tiel, G Paul Voorn, Mireille WH Wulf, Jan van Zeijl, Annet Troelstra, Marc JM Bonten, undefined MRSA Eradication Study Group

J Antimicrob Chemother | Published : 2011

Abstract

BACKGROUND: We evaluated the effectiveness of eradication of methicillin-resistant Staphylococcus aureus (MRSA) carriage in the Netherlands after the introduction of a guideline in 2006. The guideline distinguishes complicated (defined as the presence of MRSA infection, skin lesions, foreign-body material, mupirocin resistance and/or exclusive extranasal carriage) and uncomplicated carriage (not meeting criteria for complicated carriage). Mupirocin nasal ointment and chlorhexidine soap solution are recommended for uncomplicated carriers and the same treatment in combination with two oral antibiotics for complicated carriage. METHODS: A prospective cohort study was performed in 18 Dutch centr..

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