Journal article

Paraneoplastic systemic lupus erythematosus associated with colorectal cancer.

Matthew J Rees, Adam Steinberg, Evange Romas, Sharon Ford, Veena Roberts, Francesco L Ierino

Oxf Med Case Reports | Published : 2019


A 64-year-old gentleman initially presented with nephrotic syndrome and membranous nephropathy with positive staining for C1q, which was suspicious for lupus membranous nephritis. Investigation led to the simultaneous diagnosis of colorectal cancer (CRC). The CRC was surgically excised and the patient's nephrotic syndrome resolved. The patient subsequently presented with classic systemic lupus erythematosus (SLE) including positive serological markers, mouth-ulcers and a photosensitive maculopapular rash. Two months later the patient represented with an SLE flare encompassing the full-hand of renal-pulmonary syndrome and vasculitic-neuropathy, importantly at this presentation occult recurren..

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