Dissociation of Pentameric to Monomeric C-Reactive Protein on Activated Platelets Localizes Inflammation to Atherosclerotic Plaques
Steffen U Eisenhardt, Jonathon Habersberger, Andrew Murphy, Yung-Chih Chen, Kevin J Woollard, Nicole Bassler, Hongwei Qian, Constantin von zur Muhlen, Christoph E Hagemeyer, Ingo Ahrens, Jaye Chin-Dusting, Alex Bobik, Karlheinz Peter
CIRCULATION RESEARCH | LIPPINCOTT WILLIAMS & WILKINS | Published : 2009
C-reactive protein (CRP) is a predictor of cardiovascular risk. It circulates as a pentamer (pentameric CRP) in plasma. The in vivo existence of monomeric (m)CRP has been postulated, but its function and source are not clear. We show that mCRP is deposited in human aortic and carotid atherosclerotic plaques but not in healthy vessels. pCRP is found neither in healthy nor in diseased vessels. As source of mCRP, we identify a mechanism of dissociation of pCRP to mCRP. We report that activated platelets, which play a central role in cardiovascular events, mediate this dissociation via lysophosphatidylcholine, which is present on activated but not resting platelets. Furthermore, the dissociation..View full abstract
This study was supported by the National Health and Medical Research Council and the National Heart Foundation of Australia.