Induction of DNA adducts in vivo in rat lung cells by fume condensates of roofing asphalt.
HW Qian, T Ong, J Nath, WZ Whong
Teratog Carcinog Mutagen | Published : 1998
Many workers in the highway construction and roofing industries are potentially exposed to asphalt fumes. However, little is known regarding the carcinogenic hazards of these fumes to the exposed workers. Previous studies have shown that condensates of asphalt fumes are weakly mutagenic to bacteria and are capable of inducing micronucleus formation in cultured mammalian cells. In this study, the induction of DNA adducts in vivo in lung and white blood cells (WBCs) of rats by fume condensates of type I and type III roofing asphalts was investigated using 32P-postlabeling analysis. Male CD rats (3/group) received 3 intratracheal instillations of fume condensates in a 24-h period. DNA from both..View full abstract