Journal article

A prospective, cross-sectional study to establish age-specific reference intervals for neonates and children in the setting of clinical biochemistry, immunology and haematology: the HAPPI Kids study protocol

Monsurul Hoq, Vicky Karlaftis, Susan Mathews, Janet Burgess, Susan M Donath, John Carlin, Paul Monagle, Vera Ignjatovic

BMJ OPEN | BMJ PUBLISHING GROUP | Published : 2019

Abstract

INTRODUCTION: The clinical interpretation of laboratory tests is reliant on reference intervals. However, the accuracy of a reference interval is dependent on the selected reference population, and in paediatrics, the ability of the reference interval to reflect changes associated with growth and age, as well as sex and ethnicity. Differences in reagent formulations, methodologies and analysers can also impact on a reference interval. To date, no direct comparison of reference intervals for common analytes using different analysers in children has been published. The Harmonising Age Pathology Parameters in Kids (HAPPI Kids) study aims to establish age-appropriate reference intervals for comm..

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Grants

Awarded by Royal Children's Hospital Foundation


Funding Acknowledgements

This study has been primarily funded by The Royal Children's Hospital Foundation (Proposal ID: 2014 - 233), with supplementary funding from Ortho Diagnostics. In addition, the study received in-kind reagents from Roche Diagnostics. Funding bodies do not have any input in the design of the study, sample collection, analysis and interpretation of data and in preparation of the manuscript.