Journal article
Generally applicable transcriptome-wide analysis of translation using anota2seq
C Oertlin, J Lorent, C Murie, L Furic, I Topisirovic, O Larsson
Nucleic Acids Research | OXFORD UNIV PRESS | Published : 2019
DOI: 10.1093/nar/gkz223
Open access
Abstract
mRNA translation plays an evolutionarily conserved role in homeostasis and when dysregulated contributes to various disorders including metabolic and neurological diseases and cancer. Notwithstanding that optimal and universally applicable methods are critical for understanding the complex role of translational control under physiological and pathological conditions, approaches to analyze translatomes are largely underdeveloped. To address this, we developed the anota2seq algorithm which outperforms current methods for statistical identification of changes in translation. Notably, in contrast to available analytical methods, anota2seq also allows specific identification of an underappreciate..
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Grants
Awarded by Cancerfonden
Funding Acknowledgements
Swedish Research Council; Swedish Cancer Society; Cancer Society in Stockholm; Wallenberg Academy Fellows Program; STRATCAN grants (to O.L.); Canadian Institutes for Health Research [MOP-363027]; National Institutes of Health [R01 CA 202021-01-A1 to I.T.] who is a Junior 2 Research Scholar of the Fonds de Recherche du Quebec Sante (FRQ-S); Joint Canada-Israel Health Research Program (JCIHRP) [108589-001 to I.T. and O.L.]; Department of Health and Human Services acting through theVictorian Cancer Agency [MCRF16007 to L.F.]; National Health and Medical Research Council (NHMRC) [APP1141339 to O.L., I.T. and L.F.] Funding for open access charge: Vetenskapsradet.