Journal article

Intracochlear tPA infusion may reduce fibrosis caused by cochlear implantation surgery

Jessica Ky-Lee Choong, Jonathon Lo, Scott Andrew Chambers, Amy Judith Hampson, Hayden Timothy Eastwood, Stephen John O'Leary

ACTA OTO-LARYNGOLOGICA | TAYLOR & FRANCIS LTD | Published : 2019

Abstract

BACKGROUND: Experiments show that the extent of ongoing fibrotic change within the cochlea can be determined by the volume and pattern of bleeding within the first 24 h following cochlear implantation. Tissue-type plasminogen activator (tPA) is effective at reducing thrombus volume when administered both within and external to the systemic circulation. AIMS/OBJECTIVES: To determine if tPA delivered into the scala tympani immediately following implantation will reduce thrombus volume within the lower basal turn of the cochlea. MATERIALS AND METHODS: Guinea pigs were implanted with either 'soft' or 'hard' arrays and administered tPA or saline via an intra-cochlear infusion immediately after im..

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