Intracochlear tPA infusion may reduce fibrosis caused by cochlear implantation surgery
Jessica Ky-Lee Choong, Jonathon Lo, Scott Andrew Chambers, Amy Judith Hampson, Hayden Timothy Eastwood, Stephen John O'Leary
ACTA OTO-LARYNGOLOGICA | TAYLOR & FRANCIS LTD | Published : 2019
BACKGROUND: Experiments show that the extent of ongoing fibrotic change within the cochlea can be determined by the volume and pattern of bleeding within the first 24 h following cochlear implantation. Tissue-type plasminogen activator (tPA) is effective at reducing thrombus volume when administered both within and external to the systemic circulation. AIMS/OBJECTIVES: To determine if tPA delivered into the scala tympani immediately following implantation will reduce thrombus volume within the lower basal turn of the cochlea. MATERIALS AND METHODS: Guinea pigs were implanted with either 'soft' or 'hard' arrays and administered tPA or saline via an intra-cochlear infusion immediately after im..View full abstract
This research was funded in part by a generous bequest from the late Gordon Darling, AC. JKC is a recipient of the Hugh Noel Puckle Scholarship.