Journal article

On the Variable Clinical Presentation of Molar-Incisor Hypomineralization

Alexandre Rezende Vieira, David J Manton

CARIES RESEARCH | KARGER | Published : 2019


Molar-incisor hypomineralization (MIH) is a condition that is defined based on its peculiar clinical presentation. Original reports on the etiology of the condition and possible risk factors were inconclusive, and we refuted the original suggestion that MIH is an idiopathic condition and suggested that MIH has complex inheritance and is due to the interaction of more than one gene and the environment. Our group was the first to suggest MIH has a genetic component that involves genetic variation in genes expressed during dental enamel formation. Later we expanded this work to include genes related to the immune response. In this report, we provide a rationale to explain the variation seen in ..

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University of Melbourne Researchers