Journal article

Reduced Aortic Distensibility is Associated With Higher Aorto-Carotid Wave Transmission and Central Aortic Systolic Pressure in Young Adults After Coarctation Repair

Remi Kowalski, Melissa GY Lee, Lex W Doyle, Jeanie LY Cheong, Joseph J Smolich, Yves d'Udekem, Jonathan P Mynard, Michael MH Cheung

Journal of the American Heart Association | WILEY | Published : 2019


Background The long-term prognosis of patients with repaired aortic coarctation is characterized by high rates of cardiovascular and cerebrovascular disease related to hypertension, the basis of which remains unclear. To define potential underlying mechanisms, we investigated aortic and carotid arterial biomechanics and wave dynamics, and determinants of aortic systolic blood pressure, in young adults after coarctation repair. Methods and Results Aortic arch and carotid biomechanics, wave intensity and wave power, and central aortic blood pressure, were derived from echocardiography and brachial blood pressure in 43 young adults after coarctation repair and 42 controls. Coarctation subjects ..

View full abstract


Awarded by NHMRC

Awarded by Centre of Research Excellence

Awarded by National Heart Foundation of Australia (NHF)

Awarded by NHMRC Career Development Fellowship

Awarded by Heart Kids

Funding Acknowledgements

This work was supported by a National Health and Medical Research Council (NHMRC) Postgraduate Scholarship to Dr Kowalski, Heart Kids Grant-in-aid G005, NHMRC Project grant 491246, Centre of Research Excellence 1060733, the Victorian Government's Operational Infrastructure Support Program, and RCH 1000 of the Royal Children's Hospital Foundation. A/Prof d'Udekem is a NHMRC Clinician Practitioner Fellow (1082186). Dr Lee is supported by a Health Professional Scholarship from the National Heart Foundation of Australia (NHF, 100681). Dr Mynard is supported by a co-funded Career Development Fellowship/Future Leader Fellowship from the NHMRC and NHF. Dr Cheong has an NHMRC Career Development Fellowship (1141354).