Neutralising antibodies block the function of Rh5/Ripr/CyRPA complex during invasion of Plasmodium falciparum into human erythrocytes
Julie Healer, Wilson Wong, Jennifer K Thompson, Wengqiang He, Richard W Birkinshaw, Kazutoyo Miura, Carol A Long, Vladislav Soroka, Teit Max Moscote Sogaard, Thomas Jorgensen, Willem A de Jongh, Christopher Weir, Ella Svahn, Peter E Czabotar, Wai-Hong Tham, Ivo Mueller, Paul N Barlow, Alan F Cowman
Cellular Microbiology | WILEY | Published : 2019
Awarded by National Health and Medical Research Council of Australia (NHMRC)
Awarded by NHMRC
We thank Lin Chen for production of the CyRPA protein and Roma Galloway for assistance with protein production, the Victorian Red Cross Blood Bank for supply of blood and Simon Draper (Oxford University) for kindly supplying the anti-PfRh5 monoclonal antibody. Experimental data presented here were made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS. The research was supported by a National Health and Medical Research Council of Australia (NHMRC; GNT637406, GNT1020040, GNT1092789, GNT1117288, GNT1011453, GNT1057960). W. W. was supported through an Early Career Fellowship (1053801) from the NHMRC, and A. F. C. was an international scholar of the Howard Hughes Medical Institute (55007645). W. H. T. is a Howard Hughes Medical Institute-Wellcome Trust International Research Scholar (208693/Z/17/Z). The GIA analysis performed at NIAID was supported in part by the Intramural Research Program of NIAID, NIH. We thank PATH/Malaria Vaccine Initiative and USAID for direct support.