Book Chapter
Modulation of Inflammation by Antidepressants
Bernhard T Baune
INFLAMMATION AND IMMUNITY IN DEPRESSION: BASIC SCIENCE AND CLINICAL APPLICATIONS | ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD | Published : 2018
Abstract
Antidepressants have been reported to modify immune functions, and results suggest that several antidepressants may have the ability to reduce pro-inflammatory factors measured in peripheral blood. Particularly, C-reactive protein, tumor necrosis factor-a, interleukin (IL)-1β, and IL-6 have been the target proteins that show a reduction in peripheral blood levels in antidepressant trials. In addition, the effects of antidepressants on the factors of the adaptive immune system have been observed but have been less systematically investigated with inconclusive results. Since these results suggest that both the innate and possibly the adaptive immune system may be mechanistically involved in me..
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