Inflammasomes Action as an Important Mechanism in Experimental and Clinical Depression

Abstract

Depression is the most common psychiatric syndrome affecting 350 millions of people worldwide; however, the pathophysiological mechanism of depression remains elusive although a number of biological and environmental factors contribute to the illness. One hypothesis about the pathophysiology of depression that has received wide attention in the last decade is modulation of the innate immune response by the external and internal factors leading to depression. There is a clear agreement on the neuroinflammatory pathway to depression, especially during old age and systemic pathologies; however, the various components of the innate immune system involved in the neuroinflammatory pathway are stil..