Journal article
Intensification of medication and glycaemic control among patients with type 2 diabetes-The ADVANCE trial
S van Dieren, AP Kengne, J Chalmers, JWJ Beulens, TME Davis, G Fulcher, SR Heller, A Patel, S Colagiuri, P Hamet, G Mancia, M Marre, B Neal, B Williams, LM Peelen, YT van der Schouw, M Woodward, S Zoungas
Diabetes Obesity and Metabolism | Published : 2014
DOI: 10.1111/dom.12238
Abstract
Aims: The aim of this study was to assess associations between patient characteristics, intensification of blood glucose-lowering treatment through oral glucose-lowering therapy and/or insulin and effective glycaemic control in type 2 diabetes. Methods: 11140 patients from the Action in Diabetes and Vascular disease: preterAx and diamicroN-MR Controlled Evaluation (ADVANCE) trial who were randomized to intensive glucose control or standard glucose control and followed up for a median of 5years were categorized into two groups: effective glycaemic control [haemoglobin A1c (HbA1c)≤7.0% or a proportionate reduction in HbA1c over 10%] or ineffective glycaemic control (HbA1c>7.0% and a proportion..
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