Journal article
Albuminuria and kidney function independently predict cardiovascular and renal outcomes in diabetes
T Ninomiya, V Perkovic, BE De Galan, S Zoungas, A Pillai, M Jardine, A Patel, A Cass, B Neal, N Poulter, CE Mogensen, M Cooper, M Marre, B Williams, P Hamet, G Mancia, M Woodward, S MacMahon, J Chalmers
Journal of the American Society of Nephrology | Published : 2009
Abstract
There are limited data regarding whether albuminuria and reduced estimated GFR (eGFR) are separate and independent risk factors for cardiovascular and renal events among individuals with type 2 diabetes. The Action in Diabetes and Vascular disease: preterAx and diamicroN-MR Controlled Evaluation (ADVANCE) study examined the effects of routine BP lowering on adverse outcomes in type 2 diabetes. We investigated the effects of urinary albumin-to-creatinine ratio (UACR) and eGFR on the risk for cardiovascular and renal events in 10,640 patients with available data. During an average 4.3-yr follow-up, 938 (8.8%) patients experienced a cardiovascular event and 107 (1.0%) experienced a renal event...
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