Conference Proceedings

Examining flow dynamics of platelet function in micro-contractions using micro-PIV

F Akbaridoust, CM de Silva, RJ Brazilek, X Chen, FJ Tovar-Lopez, E Poon, A Ooi, A Mitchell, H Nandurkar, WS Nesbitt, I Marusic

Proceedings of the 21st Australasian Fluid Mechanics Conference, AFMC 2018 | Australasian Fluid Mechanics Society | Published : 2018

Abstract

This study examines the flow field in the near-vicinity of microcontraction-expansion geometries in microfluidic devices designed to specifically examine the impact of flow acceleration on platelet function. To this end, a set of Micron-resolution Particle Image Velocimetry (micro-PIV) measurements is conducted under a specific set of shear flow gradient conditions with both Newtonian (water) and non-Newtonian (blood analog solutions) fluids. These experiments are complemented by numerical simulations and a set of measurements at matched conditions using blood platelets labelled with DiOC6 (1µg/mL), introduced into the citrated human whole blood. Preliminary results reveal a good agreement b..

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