Journal article

Telomere Length Shows No Association with BRCA1 and BRCA2 Mutation Status

Emma Killick, Malgorzata Tymrakiewicz, Clara Cieza-Borrella, Paula Smith, Deborah J Thompson, Karen A Pooley, Doug F Easton, Elizabeth Bancroft, Elizabeth Page, Daniel Leongamornlert, Zsofia Kote-Jarai, Rosalind A Eeles

PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2014

Abstract

This study aimed to determine whether telomere length (TL) is a marker of cancer risk or genetic status amongst two cohorts of BRCA1 and BRCA2 mutation carriers and controls. The first group was a prospective set of 665 male BRCA1/2 mutation carriers and controls (mean age 53 years), all healthy at time of enrollment and blood donation, 21 of whom have developed prostate cancer whilst on study. The second group consisted of 283 female BRCA1/2 mutation carriers and controls (mean age 48 years), half of whom had been diagnosed with breast cancer prior to enrollment. TL was quantified by qPCR from DNA extracted from peripheral blood lymphocytes. Weighted and unweighted Cox regressions and linea..

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Grants

Awarded by CRUK


Awarded by Cancer Research UK


Awarded by National Institute for Health Research


Awarded by NATIONAL CANCER INSTITUTE


Funding Acknowledgements

The authors acknowledge funding from the Annabel Evans Memorial Fund, CRUK (grant numbers C5047/A13232 and C5047/A15007), NIHR support to the Biomedical Research Centre at The Institute of Cancer Research and Royal Marsden NHS Foundation Trust and the Ronald and Rita McAulay foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.