Journal article
Association of Apolipoprotein E With Intracerebral Hemorrhage Risk by Race/Ethnicity A Meta-analysis
Sandro Marini, Katherine Crawford, Andrea Morotti, Myung J Lee, Alessandro Pezzini, Charles J Moomaw, Matthew L Flaherty, Joan Montaner, Jaume Roquer, Jordi Jimenez-Conde, Eva Giralt-Steinhauer, Roberto Elosua, Elisa Cuadrado-Godia, Carolina Soriano-Tarraga, Agnieszka Slowik, Jeremiasz M Jagiella, Joanna Pera, Andrzej Urbanik, Alexander Pichler, Bjorn M Hansen Show all
JAMA NEUROLOGY | AMER MEDICAL ASSOC | Published : 2019
Abstract
Importance: Genetic studies of intracerebral hemorrhage (ICH) have focused mainly on white participants, but genetic risk may vary or could be concealed by differing nongenetic coexposures in nonwhite populations. Transethnic analysis of risk may clarify the role of genetics in ICH risk across populations. Objective: To evaluate associations between established differences in ICH risk by race/ethnicity and the variability in the risks of apolipoprotein E (APOE) ε4 alleles, the most potent genetic risk factor for ICH. Design, Setting, and Participants: This case-control study of primary ICH meta-analyzed the association of APOE allele status on ICH risk, applying a 2-stage clustering approach..
View full abstractGrants
Awarded by NIH National Institute of Neurological Disorders and Stroke
Awarded by Yale Pepper Scholar Award
Awarded by American Heart Association fellowship
Awarded by Medical Research Council
Awarded by Centre for Cognitive Ageing and Cognitive Epidemiology - Medical Research Council
Awarded by Centre for Cognitive Ageing and Cognitive Epidemiology - Biotechnology and Biological Sciences Research Council
Awarded by Spain Ministry of Health Instituto de Salud Carlos III
Awarded by NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
Awarded by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
Awarded by NATIONAL INSTITUTE ON AGING
Funding Acknowledgements
This study was funded by grants K23NS086873, R01NS103924, U01NS069763, R01NS093870, R01AG047975, R01AG026484, P50AG005134, and K23AG02872605 from the NIH National Institute of Neurological Disorders and Stroke; a Yale Pepper Scholar Award (P30AG021342) and the Neurocritical Care Society Research Fellowship (Dr Falcone); an American Heart Association fellowship (18POST34080063) (Dr Marini); and a United Kingdom Medical Research Council/Stroke Association Clinical Research Training Fellowship and a United Kingdom Medical Research Council Senior Clinical Fellowship. The Lothian Birth Cohort 1936 is supported by Age UK (The Disconnected Mind project), the Medical Research Council (MR/M01311/1), and the Centre for Cognitive Ageing and Cognitive Epidemiology (which is funded by the Medical Research Council and the Biotechnology and Biological Sciences Research Council [MR/K026992/1]). The Edinburgh Stroke Study was supported by theWellcome Trust and the Binks Trust. Sample processing occurred in the Genetics Core Laboratory of theWellcome Trust Clinical Research Facility, Western General Hospital. Much of the neuroimaging occurred in the Scottish Funding Council Brain Imaging Research Centre, University of Edinburgh, a core area of the Wellcome Trust Clinical Research Facility and part of the Scottish Imaging Network-A Platform for Scientific Excellence collaboration (funded by the Scottish Funding Council and the Chief Scientist Office). Lund Stroke Register is supported by the Swedish Heart and Lung Foundation, Region Skane, Skane University Hospital, the Freemasons Lodge of Instruction EOS in Lund, King Gustaf V and Queen Victoria's Foundation, Lund University, the Foundation of Fars & Frosta (one of Sparbanken Skane's ownership Foundations), and the Swedish Stroke Association. ICH case and control recruitment from Spain has been supported by the Spain Ministry of Health Instituto de Salud Carlos III FEDER RD16/0019/0002. INVICTUS-PLUS.