Journal article

White Matter Hyperintensity Quantification in Large-Scale Clinical Acute Ischemic Stroke Cohorts – The MRI-GENIE Study

Markus Schirmer, Adrian Dalca, Ramesh Sridharan, Anne-Katrin Giese, Kathleen Donahue, Marco Nardin, Steven Mocking, Elissa McIntosh, Petrea Frid, Johan Wasselius, John Cole, Lukas Holmegaard, Christina Jern, Jordi Jimenez-Conde, Robin Lemmens, Arne Lindgren, James Meschia, Jaume Roquer, Tatjana Rundek, Ralph Sacco Show all

Published : 2019

Abstract

White matter hyperintensity (WMH) burden is a critically important cerebrovascular phenotype linked to prediction of diagnosis and prognosis of diseases, such as acute ischemic stroke (AIS). However, current approaches to its quantification on clinical MRI often rely on time intensive manual delineation of the disease on T2 fluid attenuated inverse recovery (FLAIR), which hinders high-throughput analyses such as genetic discovery. In this work, we present a fully automated pipeline for quantification of WMH in clinical large-scale studies of AIS. The pipeline incorporates automated brain extraction, intensity normalization and WMH segmentation using spatial priors. We first propose a brain e..

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