Journal article

Use and Evaluation of Molecular Diagnostics for Pneumonia Etiology Studies

Niranjan Bhat, Katherine L O'Brien, Ruth A Karron, Amanda J Driscoll, David R Murdoch

Clinical Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2012

Abstract

Comprehensive microbiological testing will be a core function of the Pneumonia Etiology Research for Child Health (PERCH) project. The development stage of PERCH provided the time and resources necessary for us to conduct a comprehensive review of the current state of respiratory diagnostics. These efforts allowed us to articulate the unique requirements of PERCH, establish that molecular methods would be central to our testing strategy, and focus on a short list of candidate platforms. This process also highlighted critical challenges in the general design and interpretation of diagnostic evaluation studies, particularly in the field of respiratory infections. Although our final molecular d..

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Grants

Awarded by The Bill & Melinda Gates Foundation


Awarded by National Center for Research Resources (NCRR)


Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES


Funding Acknowledgements

This work was supported by grant 48968 from The Bill & Melinda Gates Foundation to the International Vaccine Access Center, Department of International Health, Johns Hopkins Bloomberg School of Public Health, and the National Center for Research Resources (NCRR) (grant 1KL2RR025006-01 to N. B.).This article was published as part of a supplement entitled "Pneumonia Etiology Research for Child Health,'' sponsored by a grant from The Bill & Melinda Gates Foundation to the PERCH Project of Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.