A temporal and spatial map of axons in developing mouse prostate
Anne E Turco, Mark T Cadena, Helen L Zhang, Jaskiran K Sandhu, Steven R Oakes, Thrishna Chathurvedula, Richard E Peterson, Janet R Keast, Chad M Vezina
HISTOCHEMISTRY AND CELL BIOLOGY | SPRINGER | Published : 2019
Prostate autonomic and sensory axons control glandular growth, fluid secretion, and smooth muscle contraction and are remodeled during cancer and inflammation. Morphogenetic signaling pathways reawakened during disease progression may drive this axon remodeling. These pathways are linked to proliferative activities in prostate cancer and benign prostate hyperplasia. However, little is known about which developmental signaling pathways guide axon investment into prostate. The first step in defining these pathways is pinpointing when axon subtypes first appear in prostate. We accomplished this by immunohistochemically mapping three axon subtypes (noradrenergic, cholinergic, and peptidergic) du..View full abstract
Awarded by National Institutes of Health
Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
Awarded by NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
This work was supported by National Institutes of Health Grants RO1ES001332, U54DK104310, T32ES007015, U01DK110807, and U01DK110807-S1.