Quality of Life and 1-Year Survival in Patients With Early Septic Shock: Long-Term Follow-Up of the Australasian Resuscitation in Sepsis Evaluation Trial
Alisa M Higgins, Sandra L Peake, Rinaldo Bellomo, D Jamie Cooper, Anthony Delaney, Anthony H Harris, Belinda D Howe, Alistair D Nichol, Steve A Webb, Patricia J Williams
CRITICAL CARE MEDICINE | LIPPINCOTT WILLIAMS & WILKINS | Published : 2019
OBJECTIVES: To examine long-term survival and quality of life of patients with early septic shock. DESIGN: Prospective, randomized, parallel-group trial. SETTING: Fifty-one hospitals in Australia, New Zealand, Finland, Hong Kong, and the Republic of Ireland. PATIENTS: One-thousand five-hundred ninety-one patients who presented to the emergency department with early septic shock between October 2008 and April 2014, and were enrolled in the Australasian Resuscitation in Sepsis Evaluation trial. INTERVENTIONS: Early goal-directed therapy versus usual care. MEASUREMENTS AND MAIN RESULTS: Long-term survival was measured up to 12 months postrandomization. Health-related quality of life was measure..View full abstract
Awarded by National Health and Medical Research Council of Australia
Awarded by National Health and Medical Research Council postgraduate scholarship
The Australasian and Resuscitation in Sepsis Evaluation trial was funded by the National Health and Medical Research Council of Australia (numbers 491075 and 1021165). Additional funding to support the long-term mortality and health-related quality of life assessments was provided by the Intensive Care Foundation.Ms. Higgins was supported to complete this work by a National Health and Medical Research Council postgraduate scholarship (number 579709). The remaining authors have disclosed that they do not have any potential conflicts of interest.