Naive regulatory T cells in infancy: Associations with perinatal factors and development of food allergy
Fiona Collier, Anne-Louise Ponsonby, Martin O'Hely, Mimi LK Tang, Richard Saffery, John Molloy, Lawrence E Gray, Sarath Ranganathan, David Burgner, Katrina J Allen, Susanne Brix, Peter J Vuillermin
Allergy | WILEY | Published : 2019
BACKGROUND: In previous studies, deficits in regulatory T-cell (Treg) number and function at birth have been linked with subsequent allergic disease. However, longitudinal studies that account for relevant perinatal factors are required. The aim of this study was to investigate the relationship between perinatal factors, naïve Treg (nTreg) over the first postnatal year and development of food allergy. METHODS: In a birth cohort (n = 1074), the proportion of nTreg in the CD4+ T-cell compartment was measured by flow cytometry at birth (n = 463), 6 (n = 600) and 12 (n = 675) months. IgE-mediated food allergy was determined by food challenge at 1 year. Associations between perinatal factors (ges..View full abstract
Awarded by National Health and Medical Research Council of Australia
We would like to thank the study participants, as well as the entire BIS team which includes interviewers, nurses, computer technicians, clerical workers, research scientists, volunteers, managers and receptionists. We also thank the obstetric and midwifery teams at Barwon Health and Saint John of God Hospital Geelong for their assistance in recruitment and collection of biological specimens. This study was funded by the National Health and Medical Research Council of Australia (607370, 1082307, 1147980), The Murdoch Children's Research Institute, Barwon Health and Deakin University.