Journal article

Lubricin on Platinum Electrodes: A Low-Impedance Protein-Resistant Surface Towards Biomedical Implantation

Saimon M Silva, Anita F Quigley, Robert M Kapsa, George W Greene, Simon E Moulton

CHEMELECTROCHEM | WILEY-V C H VERLAG GMBH | Published : 2019

Abstract

Biofouling on surfaces compromises the function of biomedical devices whose function involves contact with biological fluids. In the context of electrochemical devices, proteins are attracted to the surface via coaction of various forces (hydrogen bond, hydrophobic effect, and other polar interactions) and protein interaction with the surface can significantly alter the surface chemistry. In response to this issue, we have developed an efficient anti-biofouling surface that employs a glycoprotein, lubricin (LUB), and which generates low impedance layers compatible with electrochemical applications. Herein, we investigate how different LUB densities on platinum (Pt) electrodes affect the surf..

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Grants

Awarded by Australian Research Council


Funding Acknowledgements

We acknowledge the financial support from the Australian Research Council in the Discovery Project (DP180102287). The authors would like to thank Lubris Biopharma for supporting this research through a gift of their recombinant lubricin materials.