In vitro model of postoncosphere development, and in vivo infection abilities of Taenia solium and Taenia saginata
Sandra Palma, Nancy Chile, Rogger P Carmen-Orozco, Grace Trompeter, Kayla Fishbeck, Virginia Cooper, Laura Rapoport, Edson G Bernal-Teran, Beth J Condori, Robert H Gilman, Manuela R Verastegui, Armando E Gonzalez, Hector H Garcia, Herbert Saavedra, Manuel Martinez, Isidro Gonzalez, Manuela Verastegui, Mirko Zimic, Javier Bustos, Holger Mayta Show all
PLOS NEGLECTED TROPICAL DISEASES | PUBLIC LIBRARY SCIENCE | Published : 2019
Taenia solium is known to cause human cysticercosis while T. saginata does not. Comparative in vitro and in vivo studies on the oncosphere and the postoncospheral (PO) forms of T. solium and T. saginata may help to elucidate why cysticercosis can occur from one and not the other. The aim of this study was to use in vitro culture assays and in vivo models to study the differences in the development of the T. solium and T. saginata oncosphere. Furthermore, this study aimed to evaluate the expression of cytokines and metalloproteinases (MMPs) in human peripheral blood mononuclear cells (PBMCs), which were stimulated by these oncospheres and PO antigens. T. solium and T. saginata activated oncos..View full abstract
Awarded by Franco-Peruvian School of Life Science
Awarded by NIH
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
This work was supported by NIH grant 5D43TW006581, Infectious Diseases Training Program in Peru (RHG), http://grantome.com/grant/NIH/D43-TW006581-05; Doctoral grant of the Franco-Peruvian School of Life Science, contrato 250-2015-FONDECYT - CONCYTEC (NC), www.cienciactiva.gob.pe; Convenio No 118-2015-FONDECYT - CONCYTEC (MRV), www.cienciactiva.gob.pe; and NIH grants U19AI129909 (HHG). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.