Longitudinal assessment of rod function in intermediate age-related macular degeneration with and without reticular pseudodrusen

Abstract

PURPOSE. To evaluate rod function longitudinally in intermediate age-related macular degeneration subjects with reticular pseudodrusen (RPD) and without RPD (AMD). METHODS. Retinal sensitivities (505 and 625 nm) during dark adaptation, at 14 locations within the central 128 macula were obtained after photobleaching at baseline and 12-month visits. Pointwise sensitivity differences between both stimuli were used to assess static rod function, while rod intercept time (RIT) and rod recovery rate (RRR) were used to evaluate dynamic function. Changes in function over time were compared between groups. RESULTS. A total of 23 controls, 12 AMD, and 13 RPD cases were followed-up. At baseline, the RP..