Journal article
Harmonization of pipeline for detection of HFOs in a rat model of post-traumatic epilepsy in preclinical multicenter study on post-traumatic epileptogenesis
C Santana-Gomez, P Andrade, MR Hudson, T Paananen, R Ciszek, G Smith, I Ali, BK Rundle, XE Ndode-Ekane, PM Casillas-Espinosa, R Immonen, N Puhakka, N Jones, RD Brady, P Perucca, SR Shultz, A Pitkänen, TJ O'Brien, R Staba
Epilepsy Research | ELSEVIER | Published : 2019
Abstract
Studies of chronic epilepsy show pathological high frequency oscillations (HFOs) are associated with brain areas capable of generating epileptic seizures. Only a few of these studies have focused on HFOs during the development of epilepsy, but results suggest pathological HFOs could be a biomarker of epileptogenesis. The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy” (EpiBioS4Rx) is a multi-center project designed to identify biomarkers of epileptogenesis after a traumatic brain injury (TBI) and evaluate treatments that could modify or prevent the development of post-traumatic epilepsy. One goal of the EpiBioS4Rx project is to assess whether HFOs could be a biomarker of post-tr..
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Awarded by National Institutes of Health
Funding Acknowledgements
This research was supported by the National Institute of Neurological Disorders and Stroke (NINDS) Center without Walls of the National Institutes of Health (NIH) under Award Number U54NS100064 (EpiBioS4Rx).