Journal article

Postnatal intervention for the treatment of FNAIT: a systematic review

Jillian M Baker, Nadine Shehata, James Bussel, Michael F Murphy, Andreas Greinacher, Tamam Bakchoul, Edwin Massey, Lani Lieberman, Denise Landry, Susano Tanael, Donald M Arnold, Shoma Baidya, Gerald Bertrand, Mette Kjaer, Cecile Kaplan, Jens Kjeldsen-Kragh, Dick Oepkes, Helen Savoia, Greg Ryan, Heather Hume Show all



OBJECTIVE: Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is associated with life-threatening bleeding. This systematic review of postnatal management of FNAIT examined transfusion of human platelet antigen (HPA) selected or unselected platelets, and/or IVIg on platelet increments, hemorrhage and mortality. STUDY DESIGN: MEDLINE, EMBASE and Cochrane searches were conducted until 11 May 2018. RESULT: Of 754 neonates, 382 received platelet transfusions (51%). HPA-selected platelets resulted in higher platelet increments and longer response times than HPA-unselected platelets. However, unselected platelets generally led to sufficient platelet increments to 30 × 109/L, a level above whic..

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