Postnatal intervention for the treatment of FNAIT: a systematic review
Jillian M Baker, Nadine Shehata, James Bussel, Michael F Murphy, Andreas Greinacher, Tamam Bakchoul, Edwin Massey, Lani Lieberman, Denise Landry, Susano Tanael, Donald M Arnold, Shoma Baidya, Gerald Bertrand, Mette Kjaer, Cecile Kaplan, Jens Kjeldsen-Kragh, Dick Oepkes, Helen Savoia, Greg Ryan, Heather Hume Show all
JOURNAL OF PERINATOLOGY | SPRINGERNATURE | Published : 2019
OBJECTIVE: Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is associated with life-threatening bleeding. This systematic review of postnatal management of FNAIT examined transfusion of human platelet antigen (HPA) selected or unselected platelets, and/or IVIg on platelet increments, hemorrhage and mortality. STUDY DESIGN: MEDLINE, EMBASE and Cochrane searches were conducted until 11 May 2018. RESULT: Of 754 neonates, 382 received platelet transfusions (51%). HPA-selected platelets resulted in higher platelet increments and longer response times than HPA-unselected platelets. However, unselected platelets generally led to sufficient platelet increments to 30 × 109/L, a level above whic..View full abstract
Canadian Blood Services partially funded this study. Canadian Blood Services did not have any role in the design, analysis, and interpretation of the data or preparation, review, and approval of the manuscript.