MC1R variants in childhood and adolescent melanoma: a retrospective pooled analysis of a multicentre cohort

C Pellegrini; F Botta; D Massi; C Martorelli; F Facchetti; S Gandini; P Maisonneuve; MF Avril; F Demenais; B Bressac-de Paillerets; V Hoiom; AE Cust; H Anton-Culver; SB Gruber; RP Gallagher; L Marrett; R Zanetti; T Dwyer; NE Thomas; CB Begg; M Berwick; S Puig; M Potrony; E Nagore; P Ghiorzo; C Menin; AM Manganoni; M Rodolfo; S Brugnara; E Passoni; LK Sekulovic; F Baldini; G Guida; A Stratigos; F Ozdemir; F Ayala; R Fernandez-de-Misa; P Quaglino; G Ribas; A Romanini; E Migliano; I Stanganelli; PA Kanetsky; MA Pizzichetta; JC García-Borrón; H Nan; MT Landi; J Little; J Newton-Bishop; F Sera; MC Fargnoli; S Raimondi; M Alaibac; A Ferrari; B Valeri; M Sicher; D Mangiola; G Nazzaro; G Tosti; G Mazzarol; G Giudice; S Ribero; C Astrua; L Mazzoni; I Orlow; U Mujumdar; A Hummer; K Busam; P Roy; R Canchola; B Clas; J Cotignola; Y Monroe; B Armstrong; A Kricker; M Litchfield; P Tucker; N Stephens; T Switzer; B Theis; L From; N Chowdhury; L Vanasse; M Purdue; D Northrup; S Rosso; C Sacerdote; N Leighton; M Gildea; J Bonner; J Jeter; J Klotz; H Wilcox; H Weiss; R Millikan; D Mattingly; J Player; CK Tse; T Rebbeck; A Walker

Journal article

MC1R variants in childhood and adolescent melanoma: a retrospective pooled analysis of a multicentre cohort

C Pellegrini, F Botta, D Massi, C Martorelli, F Facchetti, S Gandini, P Maisonneuve, MF Avril, F Demenais, B Bressac-de Paillerets, V Hoiom, AE Cust, H Anton-Culver, SB Gruber, RP Gallagher, L Marrett, R Zanetti, T Dwyer, NE Thomas, CB Begg Show all

Lancet Child and Adolescent Health | Published : 2019

DOI: 10.1016/S2352-4642(19)30005-7

Abstract

Background: Germline variants in the melanocortin 1 receptor gene (MC1R) might increase the risk of childhood and adolescent melanoma, but a clear conclusion is challenging because of the low number of studies and cases. We assessed the association of MC1R variants with childhood and adolescent melanoma in a large study comparing the prevalence of MC1R variants in child or adolescent patients with melanoma to that in adult patients with melanoma and in healthy adult controls. Methods: In this retrospective pooled analysis, we used the M-SKIP Project, the Italian Melanoma Intergroup, and other European groups (with participants from Australia, Canada, France, Greece, Italy, the Netherlands, S..

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