Journal article

MC1R variants in childhood and adolescent melanoma: a retrospective pooled analysis of a multicentre cohort.

Cristina Pellegrini, Francesca Botta, Daniela Massi, Claudia Martorelli, Fabio Facchetti, Sara Gandini, Patrick Maisonneuve, Marie-Françoise Avril, Florence Demenais, Brigitte Bressac-de Paillerets, Veronica Hoiom, Anne E Cust, Hoda Anton-Culver, Stephen B Gruber, Richard P Gallagher, Loraine Marrett, Roberto Zanetti, Terence Dwyer, Nancy E Thomas, Colin B Begg Show all

Lancet Child Adolesc Health | Published : 2019


BACKGROUND: Germline variants in the melanocortin 1 receptor gene (MC1R) might increase the risk of childhood and adolescent melanoma, but a clear conclusion is challenging because of the low number of studies and cases. We assessed the association of MC1R variants with childhood and adolescent melanoma in a large study comparing the prevalence of MC1R variants in child or adolescent patients with melanoma to that in adult patients with melanoma and in healthy adult controls. METHODS: In this retrospective pooled analysis, we used the M-SKIP Project, the Italian Melanoma Intergroup, and other European groups (with participants from Australia, Canada, France, Greece, Italy, the Netherlands, S..

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