Journal article
The incidence, aetiology, and adverse clinical consequences of less severe diarrhoeal episodes among infants and children residing in low-income and middle-income countries: a 12-month case-control study as a follow-on to the Global Enteric Multicenter Study (GEMS)
KL Kotloff, D Nasrin, WC Blackwelder, Y Wu, T Farag, S Panchalingham, SO Sow, D Sur, AKM Zaidi, ASG Faruque, D Saha, PL Alonso, B Tamboura, D Sanogo, U Onwuchekwa, B Manna, T Ramamurthy, S Kanungo, S Ahmed, S Qureshi Show all
Lancet Global Health | ELSEVIER SCI LTD | Published : 2019
Abstract
Background: Diarrheal diseases remain a leading cause of illness and death among children younger than 5 years in low-income and middle-income countries. The Global Enteric Multicenter Study (GEMS) has described the incidence, aetiology, and sequelae of medically attended moderate-to-severe diarrhoea (MSD) among children aged 0–59 months residing in censused populations in sub-Saharan Africa and south Asia, where most child deaths occur. To further characterise this disease burden and guide interventions, we extended this study to include children with episodes of less-severe diarrhoea (LSD) seeking care at health centres serving six GEMS sites. Methods: We report a 1-year, multisite, age-st..
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Awarded by Bill and Melinda Gates Foundation
Funding Acknowledgements
Funding for the study was provided by the Bill & Melinda Gates Foundation (OPP1033572). We thank the children who participated in these studies and their families, and the dedicated physicians, nurses, scientists, and staff at each study site for their dedication and outstanding performance of clinical and laboratory study activities. We thank Anna Roose, Yuanyuan Liang, and Helen Powell, for their assistance with statistical analysis and Sofie Livio and Nurulla Sayed for their technical assistance in the laboratory.