Journal article
Evolving dynamic networks: An underlying mechanism of drug resistance in epilepsy?
W Woldman, MJ Cook, JR Terry
Epilepsy and Behavior | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2019
Abstract
At least one-third of all people with epilepsy have seizures that remain poorly controlled despite an increasing number of available anti-epileptic drugs (AEDs). Often, there is an initial good response to a newly introduced AED, which may last up to months, eventually followed by the return of seizures thought to be due to the development of tolerance. We introduce a framework within which the interplay between AED response and brain networks can be explored to understand the development of tolerance. We use a computer model for seizure generation in the context of dynamic networks, which allows us to generate an ‘in silico’ electroencephalogram (EEG). This allows us to study the effect of ..
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Awarded by Wellcome Trust
Funding Acknowledgements
Wessel Woldman received financial support from the Medical Research Council (via MR/N01524X/1). John R. Terry and Mark Cook received financial support from a Royal Society International Exchanges Award (grant number IE170112). John R. Terry further acknowledges the generous support of the Wellcome Trust Institutional Strategic Support Award (WT105618MA), and the EPSRC (via Centre Grant EP/N014391/1). We have no conflict of interest to declare. We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines. Full Matlab scripts will be made available on an appropriate repository (e.g., GitHub).