Brain imaging of the cortex in ADHD: A coordinated analysis of large-scale clinical and population-based samples

M Hoogman; R Muetzel; JP Guimaraes; E Shumskaya; M Mennes; MP Zwiers; N Jahanshad; G Sudre; T Wolfers; EA Earl; JC Soliva Vila; Y Vives-Gilabert; S Khadka; SE Novotny; CA Hartman; DJ Heslenfeld; LJS Schweren; S Ambrosino; B Oranje; P De Zeeuw Oranje; TM Chaim-Avancini; PGP Rosa; MV Zanetti; CB Malpas; G Kohls; GG Von Polier; J Seitz; J Biederman; AE Doyle; AM Dale; TGM van Erp; JN Epstein; TL Jernigan; R Baur-Streubel; GC Ziegler; KC Zierhut; A Schrantee; MF Høvik; AJ Lundervold; C Kelly; H McCarthy; N Skokauskas; RL O'Gorman Tuura; A Calvo; S Lera-Miguel; R Nicolau; KC Chantiluke; A Christakou; A Vance; M Cercignani; MC Gabel; P Asherson; S Baumeister; D Brandeis; S Hohmann; IE Bramati; F Tovar-Moll; AJ Fallgatter; B Kardatzki; L Schwarz; A Anikin; A Baranov; T Gogberashvili; D Kapilushniy; A Solovieva; H El Marroun; T White; G Karkashadze; L Namazova-Baranova; T Ethofer; P Mattos; T Banaschewski; D Coghill; KJ Plessen; J Kuntsi; MA Mehta; Y Paloyelis; NA Harrison; MA Bellgrove; TJ Silk; AI Cubillo; K Rubia; L Lazaro; S Brem; S Walitza; T Frodl; M Zentis; FX Castellanos; YN Yoncheva; J Haavik; L Reneman; A Conzelmann; KP Lesch; P Pauli; A Reif; L Tamm; K Konrad; E Oberwelland Weiss; GF Busatto; MR Louza

Journal article

Brain imaging of the cortex in ADHD: A coordinated analysis of large-scale clinical and population-based samples

M Hoogman, R Muetzel, JP Guimaraes, E Shumskaya, M Mennes, MP Zwiers, N Jahanshad, G Sudre, T Wolfers, EA Earl, JC Soliva Vila, Y Vives-Gilabert, S Khadka, SE Novotny, CA Hartman, DJ Heslenfeld, LJS Schweren, S Ambrosino, B Oranje, P De Zeeuw Oranje Show all

American Journal of Psychiatry | AMER PSYCHIATRIC PUBLISHING, INC | Published : 2019

DOI: 10.1176/appi.ajp.2019.18091033

Abstract

Objective: Neuroimaging studies show structural alterations of various brain regions in children and adults with attention deficit hyperactivity disorder (ADHD), although nonrepli-cations are frequent. The authors sought to identify cortical characteristics related to ADHD using large-scale studies. Methods: Cortical thickness and surface area (based on the Desikan–Killiany atlas) were compared between case subjects with ADHD (N=2,246) and control subjects (N=1,934) for children, adolescents, and adults separately in ENIGMA-ADHD, a consortium of 36 centers. To assess familial effects on cortical measures, case subjects, unaffected siblings, and control subjects in the NeuroIMAGE study (N=506..

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