Journal article

Tauopathy in the periaqueductal gray, kolliker-fuse nucleus and nucleus retroambiguus is not predicted by ultrasonic vocalization in tau-P301L mice

Pedro Trevizan-Bau, Rishi R Dhingra, Emma L Burrows, Mathias Dutschmann, Davor Stanic

BEHAVIOURAL BRAIN RESEARCH | ELSEVIER SCIENCE BV | Published : 2019

Abstract

Upper airway and vocalization control areas such as the periaqueductal gray (PAG), kölliker-fuse nucleus (KF) and nucleus retroambiguus (NRA) are prone to developing tauopathy in mice expressing the mutant human tau P301L protein. Consequently, impaired ultrasonic vocalization (USV) previously identified in tau-P301L mice at the terminal disease stage of 8-9 months of age, was attributed to the presence of tauopathy in these regions. Our aim was to establish whether the onset of USV disorders manifest prior to the terminal stage, and if USV disorders are predictive of the presence of tauopathy in the PAG, KF and NRA. USVs produced by tau-P301L and wildtype mice aged 3-4, 5-6 or 8-9 months we..

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Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by NHMRC-ARC dementia development research fellowship


Awarded by Melbourne Research Scholarship (University of Melbourne)


Funding Acknowledgements

This work was supported by the: National Health and Medical Research Council of Australia (NHMRC) [Project Grant APP1165529] to MD and DS; NHMRC-ARC dementia development research fellowship [APP1111552] to ELB; Melbourne Research Scholarship (University of Melbourne) [181858] to PT-B.