HPA axis regulation and stress response is subject to intergenerational modification by paternal trauma and stress
Vicky Batchelor, Terence Y Pang
General and Comparative Endocrinology | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2019
There is increasing evidence that one's risk for psychiatric disturbances and metabolic syndromes is influenced by their parents' own health history, lifestyle and living environment. For example, paternal high fat diet is strongly linked to neuroendocrine dysregulation in offspring and increased risk for diabetes. The potential intergenerational impact of paternal stress has only just begun to emerge, with the initial evidence suggestive of greater risk for anxiety-related disorders. The hypothalamic-pituitary-adrenal (HPA)-axis is a key neuroendocrine signalling system involved in physiological homeostasis and stress response. In individuals, dysregulation of this system is closely associa..View full abstract
TYP is funded by an NHMRC project grant.