Journal article
Risk factors for lethal arrhythmic events in children and adolescents with hypertrophic cardiomyopathy and an implantable defibrillator: An international multicenter study
Seshadri Balaji, Michael P DiLorenzo, Frank A Fish, Susan P Etheridge, Peter F Aziz, Mark W Russell, Svjetlana Tisma, Andreas Pflaumer, Narayanswami Sreeram, Peter Kubus, Ian H Law, MichalJ Kantoch, Naomi J Kertesz, Margaret Strieper, Christopher C Erickson, Jeremy P Moore, Stephanie J Nakano, Harinder R Singh, Philip Chang, Mitchell Cohen Show all
Heart Rhythm | ELSEVIER SCIENCE INC | Published : 2019
Abstract
BACKGROUND: Predictors of risk of lethal arrhythmic events (LAEs) is poorly understood and may differ from adults in children with hypertrophic cardiomyopathy (HCM). OBJECTIVE: The purpose of this study was to determine predictors of LAE in children with HCM. METHODS: A retrospective data collection on 446 children 20 years and younger (65% male; mean age 10.1 ± 5.7 years) with idiopathic HCM from 35 centers. Patients were classified as group 1 (HCM with LAE) if having a secondary prevention implantable cardioverter-defibrillator (ICD) or primary prevention ICD with appropriate interventions or group 2 (HCM without LAE) if having a primary prevention ICD without appropriate interventions. RE..
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Awarded by Medtronic
Funding Acknowledgements
This study was supported by Medtronic External Research Protocol number CR-1651. Dr Balaji has received consultancy fee from MyoKardia and serves on the advisory board of yoR labs. Dr Kubus was supported by the Ministry of Health, Czech Republic. Dr Erickson has received consultancy fee from Medtronic. Dr Moore has received research grants from Biotronik. The rest of the authors report no conflicts of interest. 1Present address: Division of Cardiology, Department of Pediatrics, Children's Hospital of San Antonio, San Antonio, Texas.