Journal article

Synaptic Basis for Contrast-Dependent Shifts in Functional Identity in Mouse V1

Molis Yunzab, Veronica Choi, Hamish Meffin, Shaun L Cloherty, Nicholas J Priebe, Michael R Ibbotson

eNEURO | Society for Neuroscience. | Published : 2019

Abstract

A central transformation that occurs within mammalian visual cortex is the change from linear, polarity-sensitive responses to nonlinear, polarity-insensitive responses. These neurons are classically labelled as either simple or complex, respectively, on the basis of their response linearity (Skottun et al., 1991). While the difference between cell classes is clear when the stimulus strength is high, reducing stimulus strength diminishes the differences between the cell types and causes some complex cells to respond as simple cells (Crowder et al., 2007; van Kleef et al., 2010; Hietanen et al., 2013). To understand the synaptic basis for this shift in behavior, we used in vivo whole-cell rec..

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Grants

Awarded by Australian Research Council Centre of Excellence for Integrative Brain Function Grant


Awarded by National Health and Medical Research Council


Awarded by National Health Institutes Grant


Funding Acknowledgements

This work was supported by the Australian Research Council Centre of Excellence for Integrative Brain Function Grant CE140100007, the National Health and Medical Research Council Grant GNT0525459, the National Health Institutes Grant EY 020592 and the L.E.W. Carty Charitable Fund & Lions Foundation of Victoria.