Journal article
SupraCells: Living Mammalian Cells Protected within Functional Modular Nanoparticle-Based Exoskeletons
Wei Zhu, Jimin Guo, Shahrouz Amini, Yi Ju, Jacob Ongudi Agola, Andreas Zimpel, Jin Shang, Achraf Noureddine, Frank Caruso, Stefan Wuttke, Jonas G Croissant, C Jeffrey Brinker
ADVANCED MATERIALS | WILEY-V C H VERLAG GMBH | Published : 2019
Abstract
Creating a synthetic exoskeleton from abiotic materials to protect delicate mammalian cells and impart them with new functionalities could revolutionize fields like cell-based sensing and create diverse new cellular phenotypes. Herein, the concept of "SupraCells," which are living mammalian cells encapsulated and protected within functional modular nanoparticle-based exoskeletons, is introduced. Exoskeletons are generated within seconds through immediate interparticle and cell/particle complexation that abolishes the macropinocytotic and endocytotic nanoparticle internalization pathways that occur without complexation. SupraCell formation is shown to be generalizable to wide classes of nanop..
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Grants
Awarded by Air Force Office of Scientific Research
Awarded by Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology
Awarded by National Health Medical Research Council
Awarded by US Department of Energy's National Nuclear Security Administration
Funding Acknowledgements
W.Z. and J.G. contributed equally to this work. This work was supported in part by the Air Force Office of Scientific Research under Grant No. FA9550-14-1-0066 and the Sandia National Laboratories Lab-Directed Research and Development Program. Part of this work was conducted and funded by the Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology (Project No. CE140100036). F.C. acknowledges the award of a National Health Medical Research Council Senior Principal Research Fellowship (APP1135806). Sandia National Laboratories is a multi-mission laboratory managed and operated by National Technology and Engineering Solutions of Sandia, LLC, a wholly owned subsidiary of Honeywell International, Inc., for the US Department of Energy's National Nuclear Security Administration under contract DENA0003525. This paper describes objective technical results and analysis. Any subjective views or opinions that might be expressed in the paper do not necessarily represent the views of the US Department of Energy or the United States Government.