Journal article

An Experimental Group A Streptococcus Vaccine That Reduces Pharyngitis and Tonsillitis in a Nonhuman Primate Model

Tania Rivera-Hernandez, Diane G Carnathan, Scott Jones, Amanda J Cork, Mark R Davies, Peter M Moyle, Istvan Toth, Michael R Batzloff, James McCarthy, Victor Nizet, David Goldblatt, Guido Silvestri, Mark J Walker

mBio | AMER SOC MICROBIOLOGY | Published : 2019

Abstract

Group A Streptococcus (GAS) infections account for an estimated 500,000 deaths every year. This bacterial pathogen is responsible for a variety of mild and life-threatening infections and the triggering of chronic autoimmune sequelae. Pharyngitis caused by group A Streptococcus (GAS), but not asymptomatic GAS carriage, is a prerequisite for acute rheumatic fever (ARF). Repeated bouts of ARF may trigger rheumatic heart disease (RHD), a major cause of heart failure and stroke accounting for 275,000 deaths annually. A vaccine that prevents pharyngitis would markedly reduce morbidity and mortality from ARF and RHD. Nonhuman primates (NHPs) have been utilized to model GAS diseases, and experiment..

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University of Melbourne Researchers