Journal article
Epigenome-wide association study for lifetime estrogen exposure identifies an epigenetic signature associated with breast cancer risk
A Johansson, D Palli, G Masala, S Grioni, C Agnoli, R Tumino, MC Giurdanella, F Fasanelli, C Sacerdote, S Panico, A Mattiello, S Polidoro, ME Jones, MJ Schoemaker, N Orr, K Tomczyk, N Johnson, O Fletcher, V Perduca, L Baglietto Show all
Clinical Epigenetics | BMC | Published : 2019
Abstract
Background: It is well established that estrogens and other hormonal factors influence breast cancer susceptibility. We hypothesized that a woman's total lifetime estrogen exposure accumulates changes in DNA methylation, detectable in the blood, which could be used in risk assessment for breast cancer. Methods: An estimated lifetime estrogen exposure (ELEE) model was defined using epidemiological data from EPIC-Italy (n = 31,864). An epigenome-wide association study (EWAS) of ELEE was performed using existing Illumina HumanMethylation450K Beadchip (HM450K) methylation data obtained from EPIC-Italy blood DNA samples (n = 216). A methylation index (MI) of ELEE based on 31 CpG sites was develop..
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Grants
Awarded by National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology
Funding Acknowledgements
This work was funded by a Breast Cancer Now PhD scholarship (2014NovPhD403).