Journal article

The role of geographical location and climate on recurrent Pseudomonas infection in young children with Cystic Fibrosis

Ranjana Warrier, Billy Skoric, Suzanna Vidmar, Rosemary Carzino, Sarath Ranganathan

Journal of Cystic Fibrosis | ELSEVIER | Published : 2019

Abstract

OBJECTIVES: To determine the association between residence and climate with risk of Pseudomonas aeruginosa (Pa) and other respiratory outcomes. METHODS: We performed regular bronchoalveolar lavage and upper airway cultures in young children with CF to identify Pa infection. Children were classified for residence as regional or metropolitan. Bronchiectasis was detected on periodic chest computed tomography scans. Multilocus sequence typing determined Pa genotype. Lung function was assessed using Multiple Breath Washout. RESULTS: Of infants diagnosed with CF between 2006 and 2017, 129 were included in the study. Seven patients moved between metropolitan and regional Victoria and were excluded ..

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