Osteosarcopenia as a Lipotoxic Disease

Abstract

Osteosarcopenia, a combination of osteoporosis and sarcopenia is characterized by a synchronic loss of bone mineral density and muscle mass, which affects an important subset of frail individuals at higher risk of institutionalization, falls and fractures. This condition has been associated with fat accumulation in bone and muscles. This fat negatively impacts cell function and structure through secretion of free fatty acids and adipokines; a phenomenon called lipotoxicity. The aim of this chapter is to summarize the role of fat infiltration in the pathogenesis of osteosarcopenia including the pathways that are affected by adipocyte-secreted factors. This chapter will also explore the curren..