Sez6 levels are elevated in cerebrospinal fluid of patients with inflammatory pain-associated conditions
Maria Roitman, Laura E Edgington-Mitchell, Jon Mangum, James Ziogas, Alexios A Adamides, Paul Myles, Hearan Choo-Bunnett, Nigel W Bunnett, Jenny M Gunnersen
PAIN REPORTS | LIPPINCOTT WILLIAMS & WILKINS | Published : 2019
Introduction: Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. Objectives: To determine whether this BACE1-shed form of Sez6 can be detected in the cerebrospinal fluid (CSF) and whether Sez6 levels in the CSF are altered in neuropathic pain or chronic inflammatory pain (IP). Methods: We analysed the CSF samples collected during surgery from patients with chronic neuropathic..View full abstract
Awarded by NHMRC
Awarded by NIH
Awarded by Department of Defense
This project was supported by NHMRC Project Grant GNT1099930 to J.M. Gunnersen, NHMRC GNT1091636 to L.E. Edgington-Mitchell, and by grants from the NIH (NS102722, DE026806, and DK118971) and the Department of Defense (W81XWH1810431) to N.W. Bunnett.