Journal article

Sez6 levels are elevated in cerebrospinal fluid of patients with inflammatory pain-associated conditions

Maria Roitman, Laura E Edgington-Mitchell, Jon Mangum, James Ziogas, Alexios A Adamides, Paul Myles, Hearan Choo-Bunnett, Nigel W Bunnett, Jenny M Gunnersen

PAIN REPORTS | LIPPINCOTT WILLIAMS & WILKINS | Published : 2019

Abstract

Introduction: Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. Objectives: To determine whether this BACE1-shed form of Sez6 can be detected in the cerebrospinal fluid (CSF) and whether Sez6 levels in the CSF are altered in neuropathic pain or chronic inflammatory pain (IP). Methods: We analysed the CSF samples collected during surgery from patients with chronic neuropathic..

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Grants

Awarded by NHMRC


Awarded by NIH


Awarded by Department of Defense


Funding Acknowledgements

This project was supported by NHMRC Project Grant GNT1099930 to J.M. Gunnersen, NHMRC GNT1091636 to L.E. Edgington-Mitchell, and by grants from the NIH (NS102722, DE026806, and DK118971) and the Department of Defense (W81XWH1810431) to N.W. Bunnett.