Journal article

Development and validation of serological markers for detecting recent exposure to Plasmodium vivax infection

Rhea Longley, Michael White, Eizo Takashima, Jessica Brewster, Masayuki Morita, Matthias Harbers, Leanne Robinson, Fumie Matsuura, Shih-Jung Zoe Liu, Connie Li-Wai-Suen, Wai-Hong Tham, Julie Healer, Christele Huon, Chetan Chitnis, Wang Nguitragool, Wuelton Monteiro, Carla Proietti, Denise Doolan, Xavier Ding, Iveth Gonzalez Show all

Published : 2018

Abstract

In order to accelerate towards malaria elimination, improved targeting of limited resources is essential. A major gap in our elimination toolkit for Plasmodium vivax malaria is the identification of individuals carrying arrested liver stages, called hypnozoites. These clinically silent but frequently relapsing hypnozoites are key to P. vivax persistence. Whilst hypnozoites cannot be directly detected, individuals who have had recent exposure to P. vivax and have not been treated are likely to harbor these parasites. By measuring IgG antibody responses to over 300 P. vivax proteins, a panel of serological markers capable of detecting exposure to P. vivax infections in the prior 9-month period..

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University of Melbourne Researchers

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