Journal article

Low levels of cerebral beta-amyloid precursor protein in experimental diabetes

JLC Bilszta, BA Rumble, JR Underwood

MEDICAL SCIENCE RESEARCH | LIPPINCOTT WILLIAMS & WILKINS | Published : 1999

Abstract

It remains controversial as to whether diabetes mellitus increases the risk of developing Alzheimer's disease. One line of evidence that may establish an association is a finding that advanced glycation endproducts (AGE) can influence β-A4 peptide aggregation in vitro. To investigate further how hyperglycaemia influences β-A4 metabolism, we have measured the precursor to β-4A, the β-amyloid precursor protein (β-APP), in streptozotocin-treated rats. Samples of brain, kidney and pancreas were collected from streptozotocin-treated and non-diabetic animals; β-APP was partially purified by centrifugation and levels measured by radioimmunoassay. In addition, AGE were measured in the sera and brain..

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University of Melbourne Researchers